EPİTELYAL OVER KANSERLERİNDE CD24 VE CD44’ÜN İMMUNOHİSTOKİMYASAL OLARAK KARŞILAŞTIRILMASI VE PROGNOSTİK DEĞERİ Immunohistochemical Comparison of Cd-24 And Cd-44 in Epithelial Ovarian Cancer And Prognostic Values

OZET Giris: Bu calismada epitelyal over kanserlerinden rezeke edilen tumor spesmenlerinde, CD 44 ve CD 24’un ekpresyonlari analiz edilerek, bu ekspresyon ve klinikopatolojik parametreler arasindaki iliskiyi analiz edilmistir. Gerec Ve Yontemler: Bu calisma, Klinigimizin Jinekolojik Onkoloji Anabilim Dali'nda tedavi edilen primer over kanseri olan 31 hastayi icermektedir. Bulgular: Anti-CD24 icin incelenen 14 seroz karsinomlu spesmende; 6 ornekte siddetli (+++) immunoreaktivite, 4 ornekte orta / siddetli (++ / +++) immunoreaktivite, 2 numunede orta / siddetli (++ / +++) immunoreaktivite, 2 ornekte hafif / orta (+ / + +) immunoreaktivite gozlendi. Bu 14 hasta CD 44 icin incelendiginde; 3 ornekte (++) modereta immunoreaktivitesi, 2 ornekte + / ++ (hafif / orta) immunoreaktivite, 9 ornekte + (hafif) immunoreaktivite gozlendi. Sonuc: CD44 immunoreaktivitesinin boyanma yogunlugunun over epitelyal kanserlerinde sagkalim orani ile iliskili oldugu, ancak istatistiksel olarak anlamli olmadigi tespit edildi. Her ne kadar CD 24 sagkalimi ile iliskinin istatistiksel olarak anlamli bulunmamasina ragmen, Over tumorlerde tanisal bir belirtec olarak kullanilabilecegi dusunuldu. Anahtar Kelimeler: Cd-24; Cd-44; Immunohistokimya; Over Kanseri. ABSTRACT Objective: The present study evaluated the CD24 and the CD44 expression in resected tumor specimens of ovarian carcinom and analyzed the correlation between this expression and the clinicopathological parameters. Material Methods: The present study included 31 patients with primary ovarian cancer who were treated in the Department of Gynecologic Oncology of our Clinic Results: 14 serous carcinomas examined for anti-CD24; severe (+++) immunoreactivity was observed in 6 samples, moderate / severe (++ / +++) immunoreactivity was observed in 4 samples, moderate (++) immunoreactivity was observed in 2 samples and mild / moderate (+ / ++) immunoreactivity was observed in 2 samples. When these 14 patients were examined for CD 44; (++) modereta immunoreactivity was observed in 3 samples, + / ++ (mild / moderate) immunoreactivity was observed in 2 samples and + (mild) immunoreactivity was observed in 9 samples. Conclusion: It was determined that the staining intensity of CD44 immunoreactivity was related to the survival rate in ovarian epithelial cancers, but it was not statistically significant. Although the association with survival of CD 24 was not found to be statistically significant, it was thought that it could be used as a diagnostic marker in over-tumors. Key words: CD24; CD44; Immunohistochemistry; Ovarian tumor