ИЗМЕНЕНИЯ ИММУННОГО СТАТУСА У ПАЦИЕНТОВ С ГЛИОМАМИ ГОЛОВНОГО МОЗГА РАЗЛИЧНОЙ СТЕПЕНИ ЗЛОКАЧЕСТВЕННОСТИ

The immune status of 58 patients with gliomaswas evaluated. Prior to surgical treatment in patients with low-grade gliomas was observed higher (p ˂0.05) the absolute number of total T-lymphocytes, Thelper cells and NK-cells compared to patients with high grade glioma. Postoperatively group grade II was observed explicit reduction in the number of CD3 + , CD3 + CD4 + , CD3 – CD56 + and increase in the population CD3 + CD8 + cytotoxic T-lymphocytes. Reducing of the number of CD3 – CD56 + lymphocytes in patients with diffuse astrocytomas and anaplastic gliomas after surgical treatment, maybe, related to the migration of these cells into the area of surgical intervention. At the same time in patients with grade III, IV gliomas was revealed an increase of the absolute number of killer T-cells. In the group of grade IV also was recorded increase in the percentage of T-reg, having a suppressor function, which may indicate a breach of anti-tumor immune response and cause suppression of the cytotoxic response in patients with highgrade gliomas.