Multicenter Clinical Investigation of Vancomycin-resistant Enterococcus Infection

Abstract Background: To understand the clinical characteristics of vancomycin-resistant Enterococcus (VRE) infection.Methods: The clinical characteristics of patients with VRE infection, members of CHINET Bacterial Drug Resistance Monitoring Network, in 2016, were analyzed and compared to patients with vancomycin-susceptible Enterococcus (VSE) infection patients.Results: Urinary tract infection was the main type, followed by bloodstream infection and intraabdominal infection. Compared to VSE infection, VRE infection is observed in more patients who have intravenous catheterization and undergo dialysis. In addition, the proportion of patients complicated with shock, multiple organ failure, and other bacterial and fungal infections is high, the clinical outcome is poor, the hospitalization expenses are high, and the hospitalization duration is prolonged. Multivariate logistic regression analysis showed that intravenous catheterization was an independent risk factor for VRE infection.Conclusions: Intravenous catheterization is an independent risk factor for VRE infection. Thus, clinical measures should be strengthened to prevent VRE infection.