Kras/p53 mediated murine model of undifferentiated pleomorphic sarcoma has an immune inert microenvironment and is an ideal model to test novel immunotherapies

Michael J. Monument,Arvind K. Singla, A. Affan,Frank R. Jirik,Kurt Hildebrand, J Kendal

Orthopaedic Proceedings（2020）

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摘要

Soft tissue sarcomas (STS) have not demonstrated favourable clinical responses to emerging immunotherapies such as checkpoint inhibitors. Studies in carcinomas and melanoma have demonstrated that t...

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关键词

undifferentiated pleomorphic sarcoma,kras/p53,murine model,immune

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