One-Pot and Gram-Scale Synthesis of 1,2-Diols Via Transition-Metal-Free Oxone-Mediated Direct Dihydroxylation of Alkenes in Water
Tetrahedron letters(2024)
Abstract
An efficient one-pot direct dihydroxylation of alkenes has been achieved. This reaction proceeds under transition-metal-free conditions and in water solution, producing the corresponding 1,2-diols in good to excellent yields. The discovery of an optimal pH environment is identified as a key factor in the current system, which ensures the generality and good functional group compatibility of this reaction. Moreover, the gram-scale dihydroxylation of alkenes was demonstrated and without significant decrease of the yield of product, making this protocol very practical.
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Key words
One-pot,Dihydroxylation,Transition-metal-free,Water solution,1,2-Diols
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