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Rapid Reduction and Strict Complete Response in Itch With Oral Difelikefalin in Subjects With Notalgia Paresthetica and Moderate-to-Severe Pruritus

Mark Lebwohl,Brian Kim,Javier Alonso-Llamazares,Zoe Diana Draelos,Kristine Nograles,Joana Goncalves, Josh Cirulli, Jennifer Mohawk,Catherine Munera, Tom Xue,Robert Bissonnette

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY（2023）

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Abstract
Background: Notalgia paresthetica (NP) is a common neuropathic itch characterized by pruritus of the upper back. The kappa-opioid receptor agonist difelikefalin (DFK) has previously demonstrated efficacy in systemic and inflammatory forms of chronic pruritus.
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notalgia paresthetica,oral difelikefalin,itch,moderate-to-severe
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