Anti-Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Despite remarkable advances in understanding the mechanisms underlying inflammation, the currently available anti-inflammatory therapies have many limitations, such as poor efficacies, low selectivity, and severe adverse effects. Bioactive materials with intrinsically anti-inflammatory activities have emerged as promising drug candidates for the treatment of inflammatory disorders. Among them, nanotherapies based on bioactive cyclodextrin (CD) materials have attracted much attention, owing to their multiple advantages, including broad availability, well-controlled structures, easy functionalization, good processibility, high cost-effectiveness, and excellent biocompatibility. This review provides a comprehensive overview of the recent advancements in the development and applications of anti-inflammatory nanoparticles (NPs) based on bioactive CD materials, with special focus on reactive oxygen species-scavenging NPs and NPs capable of regulating inflammatory cell recruitment and activation. In addition, the applications of these anti-inflammatory nanotherapies in the treatment of different acute/chronic inflammatory diseases are highlighted. Furthermore, major challenges in the clinical translation of these new generation anti-inflammatory therapies derived from bioactive CD materials are discussed. Dysregulated inflammation is closely associated with many acute/chronic diseases. Currently available anti-inflammatory agents have many limitations. Rationally engineered intrinsically bioactive materials are promising for inflammation regulation. This review summarizes and discusses different strategies for developing anti-inflammatory nanotherapies based on bioactive cyclodextrin materials and their applications in the treatment of diverse inflammatory diseases.image (c) 2023 WILEY-VCH GmbH