Dysregulation of miR144 and miR451 Expression in the Circulating Human Erythrocytes from the African American Adults

Diabetes mellitus (DM) is considered a global public health issue, affecting 463 million adults worldwide [1]. This count is estimated to rise above 640 million people by 2040 [2]. DM is caused by the failure of pancreas cells to produce insulin (Type1) or decrease insulin sensitivity (Type2). DM imposes a series of complex multi-organ and multi-system effects on the body over time and leads to cardiovascular disease, kidney failure, blindness, and nerve damage. Although many clinical procedures have been established to manage and treat DM, the underlying mechanisms of DM and its complications need to be fully understood in order to develop effective therapeutic strategies and identify novel biomarkers of disease [3].