Photoredox Synthesis of Silyl Ethers via Radical Coupling of Ketones with Hydrosilanes and [1,2]-Brook Rearrangement

An expedient synthesis of silyl ethers is reported via photocatalytic free radical coupling of ketones with hydrosilanes and subsequent [1, 2]-Brook rearrangement. This strategy features the advantages of 100 % atom economy, environmental friendliness, easily available starting materials as well as late-stage functionalization of complex molecules. An expedient and straightforward methodology for the synthesis of silyl ethers has been developed, via a visible light-promoted free radical coupling of ketones with hydrosilanes and subsequent [1, 2]-Brook rearrangement.image