Photoredox Metal-Free Synthesis of Unnatural -Silyl--Amino Acids via Hydrosilylation

An efficient, practical and metal-free methodology for the synthesis of beta-silyl-alpha-amino acid motifs via photoredox and hydrogen atom transfer (HAT) process is described. This protocol enables the direct hydrosilylation of dehydroalanine derivatives and tolerates a wide array of functional groups and synthetic handles, leading to valuable beta-silyl-alpha-amino acids with moderate to good yields.