Selective Synthesis of Symmetrical Thiosulfonates via Oxidative Coupling of Thiols Catalyzed by Diorganyl Diselenide

A straightforward methodology for the synthesis of symmetrical thiosulfonates through direct oxidative coupling of thiols is reported. Dibutyl diselenide was suitably applied as a catalyst for the selective conversion of thiols into respective thiosulfonates in good yields. Moreover, mechanistic studies revealed a radical reaction pathway for the preparation of target products. A straightforward method for the preparation of symmetrical thiosulfonates has been reported. This method allowed the synthesis of target products in good yields through direct oxidative coupling of thiols catalyzed by dibutyl diselenide. Furthermore, mechanistic studies were also performed which suggest a radical reaction pathway.image