Impact of probiotic Veillonella atypica FB0054 supplementation on anaerobic capacity and lactate

Seven healthy, physically active men (n = 3) and women (n = 4) (30.7 +/- 7.5 years, 172.7 +/- 8.7 cm, 70.4 +/- 11.6 kg, 23.6 +/- 4.1 kg/m2, 49.2 +/- 8.4 mL/kg/min) supplemented for 14 days with a placebo (PLA) or 1 3 1010 CFU doses of the probiotic Veillonella atypica FB0054 (FitBiomics, New York, NY). Participants had safety panels, hemodynamics, lactate, and anaerobic capacity assessed. Stool samples were collected to evaluate for metagenomic and metabolomic changes. Exhaustion times were not different between groups, whereas anaerobic capacity tended to shorten with PLA (61.14 +/- 72.04 s; 95% CI:-5.49, 127.77 s, p = 0.066) with no change with VA (13.29 +/- 100.13 s, 95% CI:-79.32, 105.89 s, p = 0.738). No changes in lactate, hemodynamics, or bacterial community changes were observed, whereas 14 me-tabolites exhibited differential expression patterns with VA supplementation. In conclusion, VA main-tained exercise performance that tended to decline in PLA. Supplementation was well tolerated with no changes in safety markers or reported adverse events.