GeneExt: a gene model extension tool for enhanced single-cell RNA-seq analysis
biorxiv(2024)
摘要
Incomplete gene models negatively impact single-cell gene expression quantification. This is particularly true in non-model species where often gene 3′ ends are inaccurately annotated, while most scRNA-seq methods only capture the 3′ transcript region. This results in many genes being incorrectly quantified or not detected. GeneExt leverages scRNA-seq data to refine gene annotations, enhancing biological interpretation and cross-species comparisons of cell type expression atlases.
### Competing Interest Statement
The authors have declared no competing interest.
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