Synthesis of plasmodione metabolites and¹³C-enriched plasmodione as chemical tools for drug metabolism investigation

Organic & Biomolecular Chemistry（2018）

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摘要

A 10-step synthesis of the antimalarial lead,13C18-enriched plasmodione, and of seven putative metabolites is described.

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关键词

plasmodione metabolites,drug metabolism investigation,c-enriched

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Synthesis of plasmodione metabolites and13C-enriched plasmodione as chemical tools for drug metabolism investigation