Angiotensin receptors in GtoPdb v.2023.1

Wayne Alexander,Kenneth E. Bernstein,Kevin J. Catt,Marc de Gasparo,Kh. Dhanachandra Singh,Satoru Eguchi,Emanuel Escher,Theodore L. Goodfriend, Masato Horiuchi,László Hunyady,Ahsan Husain,Tadashi Inagami,Sadashiva S. Karnik, Jacqueline Kemp,Walter G. Thomas, Pieter B.M.W.M. Timmermans,Kalyan Tirupula,Hamiyet Ünal,Thomas Unger,Patrick Vanderheyden

IUPHAR/BPS guide to pharmacology CITE（2023）

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摘要

The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, olmesartan, telmisartan, etc. are clinically used AT1 receptor blockers.

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关键词

angiotensin,receptors,gtopdb

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