Synthesis, antioxidant and antitumoral activity of new 5′-arylchalcogenyl-3′-N-(E)-feruloyl-3′, 5′-dideoxy-amino-thymidine (AFAT) derivatives

Julliano Guerin Leal, Bruna Candia Picolli,Cláudia S. Oliveira,Fernanda D. Avila da Silva,Folorunsho Bright Omage,João Batista Teixeira da Rocha, Mariana Souza Sonego,Natália Vieira Segatto,Fabiana Kömmling Seixas,Tiago Collares,Rafael Silva, Joelma M Sarturi,Luciano Dornelles,Maria A. F. Faustino,Oscar E. D. Rodrigues

New Journal of Chemistry（2022）

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摘要

A new multitarget arylchalcogenyl zidovudine derivative is disclosed. The compounds showed a prominent antioxidant and antitumoral activity with no overt sign of toxicity for in vivo evaluations.

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关键词

antioxidant,antitumoral activity,synthesis,dideoxy-amino-thymidine

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