Theraputic Approaches To High Grade B-Cell Lymphoma Double-Hit And Follicular Lymphoma With C - Myc, Bcl2 And/Or Bcl6 Rearrangements. Single Center Expirience

Anna E. Misyurina,Sergey K. Kravchenko,Alla M. Kovrigina,Elena A. Baryakh, Lubov V. Plastinina,Aminat U. Magomedova,Tatiana N. Obukhova,Ekaterina S. Nesterova,Vsevolod A. Misyurin,Andrey V. Misyurin,Andrey I. Vorobiev,Fatima E. Babaeva,Valery Savchenko

BLOOD（2017）

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摘要

Introduction. An appearance of secondary c-MYC gene rearrangement in patients with follicular lymphoma (FL) can predispose to histologic transformation of FL and aggressive clinical course of disease. Approaches to follicular lymphoma with с -MYC, BCL2 and/or BCL6 rearrangements treatment are not clearly defined.

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follicular lymphoma,bcl6 rearrangements,bcl2,b-cell,double-hit

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