Radiosensitization of glioblastoma using targeted inhibition of n-myristoylation
RADIOTHERAPY AND ONCOLOGY(2023)
摘要
N-myristoylation inhibition appears to be a novel method of radiosensitization for glioblastoma. N-myristoylation affects multiple oncogenic pathways including PARP-1 downregulation, which impedes DNA damage repair and may be what leads to radiosensitization. Future studies are aimed at further predictive markers and in vivo efficacy.
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关键词
glioblastoma,targeted inhibition,n-myristoylation
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