Transition Metal-Catalyzed Migratory Tsuji-Trost Reaction

Beyond the scope of classical Tsuji-Trost reaction, an alkene bearing a remote leaving group is not considered as a potential substrate for allylation. The concept of migratory Tsuji-Trost reaction focuses on the transformations with this type of substrates. Two pathways including olefin migration and leaving group migration to form typical allyl intermediate for following substitution have been explored to demonstrate the feasibility of this new concept. The development of migratory Tsuji-Trost reaction as a new reaction area via olefin migration or leaving group migration to generate critical pi-allyl Pd intermediate was summarized.image