P163/235 Thrombolysis and collateral flow in interhospital transfer for thrombectomy: implications for recanalization and infarct growth
Abstracts(2023)
摘要
Introduction
Collateral flow may mediate the effect between thrombolysis and macro and microvascular reperfusion in patients with large-vessel occlusion (LVO) transferred for endovascular treatment (EVT).Aim of Study
To investigate the interaction between thrombolysis and collateral flow in interhospital infarct growth and recanalization before EVT.Methods
This was a cohort study of consecutive anterior circulation LVO transferred patients from a primary stroke center (PSC) to a single comprehensive stroke center (CSC). We included patients who underwent repeated CT scans, and the rate of ASPECTS decay (RAD) was defined as (ASPECTS PSC – ASPECTS CSC) divided by the hours elapsed between scans. Collateral score was assessed in the PSC single-phase CTA on a scale from 0 to 3.Results
We included 264 transferred patients who underwent CT before EVT, of whom 91 (34.5%) received thrombolysis in PSC and 116 (43.9%) had good collaterals. RAD in each collateral score was not modified by bridging thrombolysis (mean, SD) [score 0: 1.49 (0.4) vs. 1.52 (1.1); score 1: 0.66 (0.7) vs. 0.70 (0.6); score 2: 0.33 (0.5) vs. 0.45 (0.6); score 3: 0.24 (0.4) vs. 0.23 (0.3)]. In patients with good collaterals, 7.9% of those without bridging thrombolysis recanalized before EVT, while 16.7% of patients with bridging thrombolysis recanalized. In patients with poor collaterals, recanalization was observed in 2.9% and 6.5% of patients, respectively.Conclusion
Collateral flow and thrombolysis may have a positive interaction in macrovascular recanalization. However, thrombolysis does not appear to interfere with collateral-mediated infarct growthDisclosure of Interest
Nothing to disclose查看译文
关键词
thrombolysis,thrombectomy,interhospital transfer,collateral flow
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