Positive feedback regulation ofPparγ1svandPparγ2during adipogenesis in 3T3-L1 cells

Abstract We have previously identified the novel splicing variant of mouse Pparγ ( Pparγ1sv ) and proposed the synergistic regulation of the early stage of adipocyte differentiation by Pparγ1sv and Pparγ2 . Here, we report the finding of PPARγ-binding sites within the Pparγ gene locus and its importance in adipogenesis and propose the positive feedback regulation of Pparγ1sv and Pparγ2 expression during the adipocyte differentiation of 3T3-L1 cells.