Red de Estudio de Drogas en Urgencias Hospitalarias en España (Registro REDUrHE): análisis general y comparación según asistencia en día laborable o festivo

espanolObjetivos. Conocer las caracteristicas sociodemograficas, el patron de consumo y la gravedad de los pacientes atendidos en servicios de urgencias hospitalarios (SUH) espanoles por intoxicacion por drogas (Proyecto REDUrHE) e investigar si existen diferencias entre los dias festivos y los dias laborables. Metodo. Once SUH integrantes del proyecto REDUrHE incluyeron durante 24 meses de forma consecutiva a los pacientes atendidos por sintomatologia derivada del consumo de drogas ilegales. Estas se determinaron por la historia clinica o la determinacion toxicologica. El indicador primario de gravedad fue el evento adverso combinado formado por intubacion, parada cardiorrespiratoria, ingreso en cuidados intensivos o muerte intrahospitalaria y los indicadores secundarios cada uno de estos eventos adversos considerado individualmente. Resultados. Se incluyeron 4.526 pacientes (festivo: 2.218, 49%; laborables: 2.308, 51%), con edad media de 33 anos (DE 11) y 75,5% hombres. Las drogas mas frecuentemente involucradas fueron cocaina (47,8%), cannabis (44,4%), derivados anfetaminicos (25,5%), benzodiacepinas (8,8%) y opiaceos (7,3%). Los pacientes atendidos en festivos eran mas jovenes (32,1 vs 33,1 anos, p = 0,006) y mas frecuentemente traidos al SUH en ambulancia (60,5% vs 57,3%, p = 0,035). Los SUH de grandes ciudades (Barcelona, Madrid) tuvieron la mayor afluencia en festivo (55,8%) y los de zonas de alto turismo ludico (Baleares, Canarias) los de menor afluencia (44,7%; p Conclusion. Las intoxicaciones por drogas atendidas en SUH en dia festivo suceden con mayor frecuencia en grandes ciudades y presentan ciertas caracteristicas distintivas (pacientes mas jovenes, mas ingesta conjunta con etanol, menos combinacion de drogas, mas frecuente gamma-hidroxibutirato y menos frecuente opiaceos). Durante los festivos, las intoxicaciones atendidas son de mayor gravedad. EnglishObjectives. To describe the sociodemographic characteristics, drug use patterns, and the severity of drug overdoses treated in hospital emergency departments according to the registry of the Spanish Research Network on Drugs in Hospital Emergency Departments (REDUrHE project), and to identify differences between patterns on weekdays and weekends/national holidays. Methods. Eleven hospitals participated in the REDUrHE project, studying consecutive patients with symptoms of drug overdose over a 24-month period. The drugs implicated were extracted from clinical records or toxicology reports. An overdose was considered severe if management required intubation, cardiopulmonary resuscitation, or admission to the intensive care unit, or if in-hospital death occurred (composite event). Each of these variables was also analyzed by itself. Results. A total of 4526 patients were studied (2218 [49%] on weekends/holidays; 2308 [51%] on workdays). The mean (SD) age was 33 (11) years, and 75.5% were men. The most commonly used drugs were cocaine (47.8%), cannabis (44.4%), amphetamine derivatives (25.5%), benzodiazepines (8.8%), and opioids (7.3%). Patients treated on weekends/holidays were younger (32.1 vs 33.1 years on weekdays, P = .006), and they were more often taken to the hospital in an ambulance (60.5% vs 57.3%, P = .035). Hospitals in large cities (Barcelona and Madrid) saw more patients on weekends/holidays (55.8%). Major tourist destinations (the Balearic and Canary Islands) saw fewer patients on weekends/holidays (44.7%, P Conclusions. Weekend and holiday emergencies due to drug overdoses are more frequent in large city hospitals. Weekend emergencies share certain distinctive characteristics: patients are younger, alcohol more often is ingested with drugs but multiple-drug combinations are less common, and GHB is used more often while opioids are used less often. Severe poisonings occur more often on weekends and holidays.