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Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique

Carla Mariner-Llicer, Belen Saavedra Cervera, Edson Mambuque, Neide Gomes, Shilzia Munguambe, Luis Villamayor, Irving Cancino-Munoz, Manuela Torres-Puente, Dinis Nguenha, Durval Respeito, Gustavo Tembe, Mariana G. Lopez, Inaki Comas, Alberto L. Garcia-Basteiro

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2024）

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Abstract
Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate detection of antimicrobial-resistance in the country.
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Key words
Mycobacterium tuberculosis,whole-genome sequencing,resistance conferring mutations,Mozambique
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