Development of Bing-Neel syndrome Despite Ibrutinib Therapy for Waldenstrom Macroglobulinemia: Next Steps in Management and Review of Future Directions

Bing-Neel syndrome (BNS) remains a rare complication of Waldenstrom Macroglobulinemia. Given the paucity of this disease, treatment guidelines are based on small clinical trials with limited participants. Here we present a case of BNS that developed while on ibrutinib therapy, followed by a review of the next steps in management.