CD4 ⁺ T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis

Science immunology（2020）

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摘要

Activation by multi-epitope peptide plus mTOR inhibition depletes flagellin-reactive CD4 + T cells and prevents intestinal inflammation.

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关键词

colitis,concomitant mtor metabolic inhibition,cells,microbiota-specific

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CD4 + T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis