Aminotriazine 5-HT7 antagonists

Ronald J. Mattson,Derek J. Denhart,John D. Catt,Michael F. Dee,Jeffrey A. Deskus,Jonathan L. Ditta,James R. Epperson,H. Dalton King,Aiming Gao,Michael A. Poss,Ashok V. Purandare,David R. Tortolani,Yufen Zhao,Hua Yang,Suresh Yeola,Jane M. Palmer,John Torrente,Arlene Stark,Graham Johnson

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

The present studies have identified a series of aminotriazines as novel 5-HT7 receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT7 receptor and do not bind to either the 5-HT2C or 5-HT6 receptors. These compounds produce no agonist effects by themselves, and shift the dose–response curve of 5-CT to the right in the manner of an antagonist.

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antagonists

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