A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans -Signaling and Cellular Infection with SARS-CoV-2

Julia Ettich,Julia Werner,Hendrik T. Weitz,Eva Mueller,Roland Schwarzer,Philipp A. Lang,Jürgen Scheller,Jens M. Moll

Journal of Virology（2022）

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Abstract

The availability of effective SARS-CoV-2 vaccines is a large step forward in managing the pandemic situation. In addition, therapeutic options, e.g., monoclonal antibodies to prevent viral cell entry and anti-inflammatory therapies, including glucocorticoid treatment, are currently developed or in clinical use to treat already infected patients.

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