Clinical observation of sequential stages of Chinese medicine treatment on mild to moderate ulcerative colitis

objective: To evaluate the remission rate,safety and the rate of recurrence of within 6 months after remission of the sequential stages of Chinese medicine treatment on mild to moderate ulcerative colitis.Methods: According to the multi-center,randomized,controlled,noninferiority study design,239 patients with mild to moderate ulcerative colitis in the four clinical centers were treated with sequential stages of Chinese medicine treatment(experimental group) or positive control drug mesalazine enteric-coated tablets treatment(control group) for 24 weeks,and compared with the remission rate,recurrence of within 6 months after remission and safety of two groups.Results: In the end of treatment,the response rate of Chinese medicine treatment group was 77.5%;comparison group was 74.2%,in the non-inferiority test,the response rate of experimental group is non-inferiority to mesalazine enteric-coated tablets control group(P0.05).And followed up for 6 months,the recurrence rate of treatment group was significantly lower than the control group(P0.05).Security monitoring shows that there was no statistically significant difference the incidence of adverse reactions of the experimental group and the control group.Conclusion: For mild to moderate ulcerative colitis patients,the clinical remission rate of traditional Chinese medicine treatment program for sequential stages is non-inferiority to mesalazine enteric-coated tablets,and the security of Chinese medicine experimental group is better and the recurrence rate can be significantly reduced within 6 months after treatment.