Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study

Xingmei Yang,Stéphanie Leroux,Thomas Storme,Daolun Zhang,Tiphaine Adam de Beaumais,Haiyan Shi,Yilei Yang,Xiaoling Wang,Wei Zhao,Evelyne Jacqz‐Aigrain

Antimicrobial Agents and Chemotherapy（2019）

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摘要

We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination.

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关键词

caspofungin,pharmacokinetics,area-based

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