Pharmacokinetic analysis of striatal D2R availability with F-18-DMFP PET in a rodent model of depression

Raissa Berti,Lidia Miguel Telega, N. Steinacker,Lisa-Charlotte Domogalla, Mohamed Aymen Omrane,Ganna Blazhenets,Lars Frings,Joachim Brumberg,Volker A. Coenen,PT Meyer,Màtè Döbrössy,Ann-Christin Eder

Nuklearmedizin-nuclear Medicine（2023）

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摘要

Ziel/Aim Reserpine (RES) is used in preclinical studies to evoke depression-like symptoms. In this study, we employed F-18-desmethoxyfallypride (F-18-DMFP) PET for the evaluation of striatal dopamine D2/D3 receptor (D2R) availability in rodents to explore the mechanisms of depression induced by RES.

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关键词

striatal d2r availability,depression,rodent model,pharmacokinetic analysis

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