Front Cover: Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity (ChemMedChem 5/2023)

The Front Cover shows fish representing fenoprofen analogues. In contrast to the phenyl analogue (left pufferfish), the carborane derivative (right inflated carboranefish) is more cytotoxic. Fenoprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) against rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis, and gout, but has also shown promising cytotoxic properties. The structural modification of fenoprofen using bulky dicarba-closo-dodecaborane(12) (carborane) clusters and the biological evaluation of the carborane analogues for COX inhibition and antitumor potential show that the carborane analogues exhibit stronger antitumor activity compared with their respective aryl-based compounds. Artwork provided by Dr. Christoph Selg. More information can be found in the Research Article by Liridona Useini, Evamarie Hey-Hawkins et al.