The mutational landscape of human somatic and germline cells

Luiza Moore,Alex Cagan,Tim Coorens, Matthew D. C. Neville,Rashesh Sanghvi,Mathijs A. Sanders, Thomas R. W. Oliver,Daniel Leongamornlert, Peter Ellis,Ayesha Noorani, Thomas J. Mitchell,Timothy Butler,Yvette Hooks,Anne Y. Warren,Mette Jørgensen,Kevin J. Dawson,Andrew Menzies,Laura P. O’Neill,Calli Latimer,Mabel Teng,Boxtel Ruben van, Christine A. Iacobuzio‐Donahue,Iñigo Martincorena,Rakesh Heer, Peter J. Campbell,Rebecca Fitzgerald,Michael R. Stratton,Raheleh Rahbari

Yearbook of pediatric endocrinology（2022）

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摘要

Brief Summary: This study investigated the mutational background of somatic cells and rates of mutation in 29 distinct anatomical structures and compared these with the male germline from the same donor. The rate of mutation was lowest in spermatogonia.

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mutational landscape,cells

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