Back Cover: DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling (Angew. Chem. Int. Ed. 41/2022)

Christian E. Stieger,Yerin Park, Mark A. R. de Geus,Dongju Kim,Christiane Huhn, Julie Sophia Slenczka,Philipp Ochtrop, Judith Maria Müchler,Roderich D. Süssmuth,Johannes Broichhagen,Mu‐Hyun Baik,Christian P. R. Hackenberger

Angewandte Chemie International Edition（2022）

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摘要

The fast and the furious: A computational DFT booster to accelerate cysteine bioconjugation: In their Research Article (202205348), Mu-Hyun Baik, Christian P. R. Hackenberger, and co-workers introduce ethynyl-triazolyl-phosphinates (ETPs) as modular electrophiles for the straightforward incorporation into complex payloads and proteins for modular protein- and antibody-modification strategies (cover picture: Barth van Rossum, FMP).

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chemoselective cysteine bioconjugation,modular electrophiles

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