Small Extracellular Vesicles from OSA Patients express Fetuin A

Obstructive sleep apnea (OSA) is a common disorder. Untreated it is believed to be a stressor for many disorders, especially for cardiovascular conditions. Continuous positive airway pressure (CPAP) is the standard treatment. The glycoprotein Fetuin-A (FA) is mainly synthesized in the liver and secreted in the bloodstream. Its functions are diverse: Studies have not only shown a correlation with insulin resistance and risk for diabetes but also still unclear involvement in cardiovascular diseases. In this study we analyzed how the content of small extracellular vesicles (sEV) differs between OSA patients in comparison to a healthy population (HD) and if it changes due to OSA treatment.