Carcinoma lobular pleomórfico de mama em cadela submetida ao tratamento quimioterápico com carboplatina - Relato de caso

ABSTRACT. D’Assis M.J.M.H., Silva L.P., Machado M.C. de A., Nascimento N.A., Damasceno K.A., Cassali G.D. & Estrela-Lima A. [Pleomorphic lobular carcinoma of the mammary gland in female dog subject to chemotherapy with carboplatin - Case report.] Carcinoma lobular pleomorfico de mama em cadela submetida ao tratamento quimioterapico com carboplatina - Relato de caso. Revista Brasileira de Medicina Veterinaria, 38(Supl.1):139-146, 2016. Programa de Pos-Graduacao Ciencia Animal nos Tropicos, Universidade Federal da Bahia, Av. Adhemar de Barros, 500, Ondina, Salvador, BA 40170-110, Brasil. E-mail: alestrela@gmail.com The objective of this report was present and discuss a Pleomorphic lobular carcinoma case incipient in canine female, 12 years old, Poodle, attended the Veterinary Medicine Hospital of the Federal University of Bahia (UFBA). For this, they were highlighted data relating to clinical, anatomical and histological, immunohistochemical and therapeutic. The final diagnosis was established by histopathological examination which revealed individual cells arranged in “single file”, or dispersed in the stroma cells with sometimes bizarre and multinucleated, and intense nuclear pleomorphism and high rate mitotic. Immunohistochemical evaluation was performed to better characterize the tumor and aid in therapeutic management. The indicated treatment was chemotherapy with carboplatin, however there was progression of the disease and the animal died 54 days after surgery. This report describes at the first time the canine Pleomorphic lobular carcinoma in its initial stage, contributing to the understanding of the biological feature of this tumour.