Dual-ModalFexCuySe andUpconversion Nanoparticle Assemblies for IntracellularMicroRNA-21 Detection
Figshare documentation (Figshare (United Kingdom))(2020)
摘要
In
situ quantification and imaging of low-level intracellular microRNAs
(miRs) are important areas in biosensor research. Herein, DNA-driven
FexCuySe@upconversion
nanoparticle (UCNP) core@satellite nanostructures were developed to
probe microRNA-21 (miR-21). FexCuySe@UCNP probes displayed dual signals: upconversion
luminescence (UCL) and magnetic resonance imaging (MRI). In the presence
of miR-21, the luminescence signal was restored and the T2 value was significantly increased because of dissociation
of UCNPs from the assemblies. There was a good linear relationship
between the dual signals and the expression levels of miR-21 in the
range of 0.035–31.824 amol/ngRNA. The limit of detection
(LOD) was 0.0058 amol/ngRNA for the luminescence intensity
and 0.0182 amol/ngRNA for the MRI signal. This method opens
a new avenue for intracellular miR-21 detection with high sensitivity
and specificity.
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关键词
nanoparticle,dual-modalfexcuyse
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