Two Epothilones from Sorangium cellulosum Strain So0157-2

Abstract Aim To study the chemical constituents of Sorangium cellulosum So0157-2. Methods The chemical constituents were isolated and purified by column chromatography, and their structures were identified by spectroscopic analyses including 1D-, 2D-NMR data and MS analyses. Results Two epothilones were purified and identified as seco-epothilone A (1) and 1-methyl-seco-epothilone A (2). Conclusion 1 and 2 were obtained from this strain for the first time, and 1 was a new natural product.