Anxiety and Depression Symptoms Disrupts Resting State Networks in Patients with Generalized Epilepsies (P3.286)

Objective: To investigate dysfunction on brain connectivity associated with anxiety and depression on Idiopathic generalized epilepsies (IGE) Background: Although previous studies on Idiopathic generalized epilepsies (IGE) revealed structural and functional brain alterations, the impact of anxiety and depression symptoms on large-scale resting state networks (RSNs) have not been entirely explored. Design/Methods: Both Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to 38 IGEPATIENTS and 38 CONTROLS (age and gender matched), along with 3T Resting-state functional MRI. We used UF2C-toolbox (running on MATLAB2014/SPM12), for parcellation of 12 RSNs [70 regions of interest (ROIs)], matrix construction and statistical analyses (with intranetwork and internetwork connectivity). Patients were divided into four groups, according to BDI and BAI scores: those with minimal and mild anxiety OR depression symptoms were classified in Anxiety-NEG (n = 27) and Depression-NEG (n = 26) respectively; those with moderate and severe anxiety OR depression symptoms were classified in Anxiety-POS (n = 11) and Depression-POS (n = 12) respectively. For group comparisons, we used t-tests between groups, applying p Results: Overall, RSNs dysfunction was detected as the four groups presented diminished connectivity between the Dorsal DMN (Default Mode Network) and Visuospatial network; between Ventral DMN and Left Executive Control Network (LECN). Both Depression-POS and Anxiety-POS displayed reduced correlation within the Visuospatial network (intranetwork connectivity). Moreover, these two groups exhibited opposite connectivity between Ventral DMN and LECN. Despite similarities, Anxiety-POS demonstrated increased connectivity between the Ventral DMN and LCEN and reduced connectivity between the Anterior and Posterior Salience Networks. Conclusions: These results suggest that depression and anxiety disorders affect differently brain connections in IGE patients; with Anxiety-POS presenting more extensive network dysfunction. Further investigation with larger cohorts is necessary to confirm the interaction between mood and dysfunctional networks. Disclosure: Dr. dos Santos Garcia has nothing to disclose. Dr. Nogueira has nothing to disclose. Dr. Alvim has nothing to disclose. Dr. Polydoro has nothing to disclose. Dr. Ishikawa has nothing to disclose. Dr. Zanao has nothing to disclose. Dr. de Campos has nothing to disclose. Dr. Lodi Montanher has nothing to disclose. Dr. Morita has nothing to disclose. Dr. Cendes has nothing to disclose. Dr. Yasuda has nothing to disclose.