ПАРАДОКСЫ РЕПЕРФУЗИИ В ПРАКТИКЕ КРИТИЧЕСКИХ СОСТОЯНИЙ: ВОЗМОЖНОСТЬ РЕШЕНИЯ

The study aims to clarify the pathogenetic factors of ischemia/reperfusion syndrome in critical conditions. Material and methods. The 122 open scientific publications in Pubmed, Medline, Embase, and e-Library.ru databases are analyzed. Data from 44 articles are included in the study. Results. The review presents modern literary data on ischemia/reperfusion syndrome, clarifying pathogenetic factors that determine the main damaging determinants. The authors draw attention to the factors influencing the severity of reperfusion damage, with an emphasis on the role of the oxygen paradox of reperfusion, potentiating free-radical oxidation in the presence of free iron ions, and damage to the respiratory chain of mitochondria. These factors, according to research, are the basis of the development of endothelial dysfunction, which causes the formation of multiple organ dysfunction syndrome in a number of critical conditions.