ВЗАИМОДЕЙСТВИЕ ТКАНЕВЫХ МАКРОФАГОВ И ТУЧНЫХ КЛЕТОК КАК НАЧАЛО ОРГАННОГО РЕМОДЕЛИРОВАНИЯ В РАМКАХ ХРОНИЧЕСКОЙ ТОКСИЧНОСТИ НАНОЧАСТИЦ КРЕМНЕЗЕМА

We studied 12-16 nm spherical silicone dioxide nanoparticles chronic toxicity on Wistar male rats (middle weight 250-300 g). We intravenously injected 1 ml silicone dioxide nanoparticles suspension and evaluated histological modifications in organs after 7, 21 and 60 days after injection. We detected mast cell migration into lungs, myocardium and liver tissues. Also we revealed macrophage granulomas around foreign bodies formation and liver tissue fibrous remodeling. This remodeling took place without precedence of destruction. We noticed that silicone dioxide nanoparticles injection was accompanied by evolution of chronic aseptic productive inflammation. The same type of inflammation take place in case of non-modified nanoparticles silicone dioxide intervention in sylicosis.