Fuzheng Huayu Capsules Combined with Nucleoside Antiviral Drug in the Treatment of Chronic Hepatitis B Liver Fibrosis:A Systematic Review

OBJECTIVE:To evaluate the efficacy and safety of Fuzheng huayu capsule combined with nucleoside antiviral drugs for chronic hepatitis B liver fibrosis.METHODS:Retrieved from CBD,Wanfang database,CSJD,CNKI,PubMed,EMBase and related journals,literatures meeting inclusion criteria were collected.Meta-analysis was performed by RevMan 5.0 software.RESULTS:10 RCT were included,involving 792 cases of chronic hepatitis B.Results of Meta-analysis showed:after treatment of 24 and 48 weeks,hyaluronic acid in the experimental group were better than the control group,the differences were statistically significant [MD=-65.80,95%CI(-90.88,-40.73),MD=-82.40,95%CI(-140.99,-23.81)],and Laminin in the experimental group were better than the control group,the differences were statistically significant [MD=-29.08,95%CI(-36.57,-21.59),MD=-68.89,95%CI(-107.45,-30.33)];After the treatment of 24 weeks,procollagen type Ⅲ in the experimental group was better than the control group,the differences were statistically significant [MD=-27.70,95%CI(-47.86,-7.55)],the experimental group was still better than the control group at 48 weeks,but the difference was not statistically significant [MD=-61.69,95%CI(-124.50,1.12)];After the treatment of 24 and 48 weeks,collagen type Ⅳ(C Ⅳ) in the experimental group were better than the control group,the differences were statistically significant [MD=-27.77,95%CI(-36.18,-19.36),MD=-57.58,95%CI(-104.42,-10.74)].There were no statistically significant in both group of safty.CONCLUSION:The effect of Fuzheng huayu capsules combined with nucleoside antiviral drug is better than antiviral nucleoside antiviral drug alone in the treatment of chronic hepatitis B liver fibrosis.And adverse effect of liver and kidney hardly appear,but limited by the quality of included studies,the above conclusions still need high-quality clinical trials for further confirmation.