Effects of auriculotherapy on anxiety and biomarkers in Primary Health Care: a clinical trial

Objective:to assess the effects of auriculotherapy on anxiety and brain-derived neurotrophic factor (BDNF), neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) serum levels in adults assisted in Primary Health Care. Methods: a pre-experimental pilot clinical trial. Information was obtained from 19 patients using the State-Trait Anxiety Inventory (STAI) and analysis of BDNF, NSE and S100B serum levels. Results:the pre-intervention anxiety score in the IDATE-Trait was 52.11 +/- 6.691 (CV 12.84%) and the assessment after auriculotherapy was significantly lower (43.72 +/- 8.141; CV 18.62%; P=0.0007). S100B levels were significantly reduced after auriculotherapy (from 64.03 +/- 72.18 to 54.03 +/- 68.53 pg/mL; CV 126.8%; P=0.0023). Conclusion: auriculotherapy effectively reduced anxiety levels. It proved to be safe and easy to apply, allowing nurses to perform this technique autonomously. A reduction of S100B was also evidenced, demonstrating possible prevention of neuronal damage.