Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: synthesis, characterization, properties and cytotoxic activity

The synthesis, identification and evaluation of the biological activity of a new non-covalent conjugate based on graphene oxide and (5-{[4,6-di(aziridin-1-yl)-1,3,5-triazin-2-yl]-amino}2,2-dimethyl-1,3-dioxan-5-yl)methyl (5-phenyl-2H-tetrazol2-yl)acetate were carried out. It was shown that the synthesized nanoconjugate is hemocompatible over the entire studied concentration range (10-100 mM) and demonstrates antiradical activity under irradiation. In addition, the conjugate exhibits cytotoxicity against A549 and HeLa cell lines with IC50 values of 4.0 and 73.7 mM, respectively.