On-demand detachable adhesive hydrogel based on dual dynamic covalent cross-linked with NIR/pH dual-responsive properties for diabetic wound healing

A novel CFE adhesive hydrogel was constructed as a multifunctional dressing material for diabetic wound healing. The CFE adhesive hydrogels exhibited good mechanical strength (adhesive, injectable, moldable and self-healing), pH-responsive EGCG release and photothermal properties, as well as excellent antimicrobial, anti-oxidant, anti-inflammatory and angiogenic activity. Additionally, the CFE adhesive hydrogels could be detached on-demand by spraying natural organic acid.