Enantioselective synthesis of spiroimidazolones by synergistic catalysis
CATALYSIS TODAY(2024)
摘要
The present study investigates an enantioselective cyclization of enals with imidazolone derivatives catalyzed by a combination of achiral Pd(0) complex and chiral secondary amine. Corresponding spirocyclic imidazolones were produced in high yields with moderate diastereoselectivity and excellent enantioselectivity. The developed co-operative catalytic methodology provides a highly substituted spirocyclic scaffold with four stereogenic centers under mild conditions.
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关键词
Asymmetric synthesis,Synergistic catalysis,Spirocyclic compounds,Imidazolones
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