Inferring molecular mechanisms of host-microbe-drug interactions in the human gastrointestinal tract

B. Roja,S. Saranya,L. Thamanna,P. Chellapandi

Medicine in Omics（2024）

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Abstract

•Constructed a systems medicine framework with 1370 interacting human genes.•Unravelled metabolic interplay between host-microbe interactions.•Linoleic acid has been identified as a cross-talk metabolite among gut microbes.•Identified suitable drug combinations to combat food-borne infections.•Identified common human genes targeted by gut methanogens.

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Key words

Clostridium botulinum,Comorbidity,Drug repurposing,Gut microbes,Network biology,Systems medicine

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