Front Cover: Development of Enterovirus Antiviral Agents That Target the Viral 2C Protein (ChemMedChem 10/2023)

The Front Cover shows a small molecule inhibitor docked into a novel pocket of the Picornavirus EV-A71 2C protein. The pocket is an ideal target for antivirals since it is highly conserved and plays a critical role in the formation of the functional 2C hexamer. The background illustrates an icosahedron tunnel depicting the various life cycle stages the viral 2C protein is involved in, and the small molecule inhibitor signifies the light at the end of the tunnel for the development of antivirals. More information can be found in the Research Article by Rishabh Kejriwal, Simon J. White et al..