Structure-based Development of Potent and Selective Type-Ii Kinase Inhibitors of RIPK1

Ying Qin,Dekang Li,Chunting Qi,Huaijiang Xiang,Huyan Meng,Jingli Liu,Shaoqing Zhou,Xinyu Gong,Ying Li, Guifang Xu,Rui Zu,Hang Xie,Yechun Xu, Gang Xu,Zheng Zhang, Shi Chen,Lifeng Pan,Li Tan

ACTA PHARMACEUTICA SINICA B（2024）

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关键词

RIPK1,Necroptosis,Type-II kinase inhibitors,Rational design,Lead optimization,Structure-activity relationship,Anti-inflammation,Preclinical drug discovery

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