Characterization of Chitosan-Gallic Acid Graft Copolymer for Periodontal Dressing Hydrogel Application

The postoperative periodontal wound is in a complex physiological environment; the bacteria accumulation, the saliva stimulation, and the food residues retention will aggravate the wound deterioration. Commercial periodontal dressings have been widely used for postoperative periodontal treatment, and there still exists some problems, such as poor biocompatibility, weak adhesion, insufficient antibacterial, and anti-inflammatory properties. In this study, a chitosan-gallic acid graft copolymer (CS-GA) is synthesized as a potential periodontal dressing hydrogel. CS-GA possesses high swelling rate, adjustable degradability, self-healing ability, biocompatibility, strong adhesion ability, high mechanical properties and toughness. Furthermore, CS-GA has good scavenging ability for center dot OH, O2-, and 1O2. And CS-GA has good inhibition effect on different bacterial through bacterial membranes damage. CS-GA can stop bleeding in a short time and adsorb erythrocytes to form physical blood clots to enhance the hemostatic performance. In addition, CS-GA can reduce inflammatory factors expressions, increase collagen fibers deposition, and neovascularization to promote wounds healing, which makes it as a potential periodontal dressing for postoperative tissue restoration. Inspired by the inherent hemostatic and antibacterial properties of chitosan and the wet-adhesion properties of mussels, a mussel-like bioadhesive hydrogel CS-GA is developed as a periodontal dressing hydrogel. CS-GA possesses multiple desirable physio-chemical properties, including biocompatibility, wet-adhesion, self-healing, hemostatic, antioxidant, and antibacterial activities, suitable for wound healing in postoperative tissue restoration.image