Cantilever Actuator Capsule for Magnetically Triggered Drug Delivery in the GI Tract

In this research, we present the development of a simple reed switch enabled magnetically triggerable electronic actuation system for protection and localized delivery of drugs in the intestinal tract. This system relies on polymeric cantilevers that can be multiplexed and released on command by melting the adhesive that holds them in compression. These cantilevers are conformally wrapped around the capsule and hold drug-loaded microneedles that penetrate the intestinal tissue to release drugs when deployed. We demonstrate the assembly, modeling, mechanical characterization, and deployment of this actuation capsule. COMSOL analysis suggested cantilever thickness of 254 mu m is ideal to achieve the desired actuation force. This result was corroborated by mechanical experiments, and deployment was achieved using a handheld magnet in 2.3 seconds. Overall, this system provides the potential for targeted drug delivery in the GI tract, improving drug efficacy while minimizing side effects.